Parkinson's disease-like sleep and motor problems observed in alpha-synuclein mutant mice

In the quest for an animal model of Parkinson's disease that mimics motor and non-motor symptoms of human Parkinson's disease (PD), scientists have developed strains of mice that overexpress alpha-synuclein. By studying a strain of mice bred to overexpress alpha-synuclein via the Thy-1 promoter, scientists have found these mice develop many of the age-related progressive motor symptoms of PD and demonstrate changes in sleep and anxiety.

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